An alternative theory of cancer as a metabolic disease was put forth by the Nobel Otto Warburg in the 1930s.
The principal proponent of this theory today is Thomas Seyfried of Boston College. Seyfried cites evidence that damage to the nuclear DNA, conventionally thought to be a root cause of cancer, is actually an effect of the damaged mitochondria and irregular metabolism. “The metabolic waste products of fermentation can destabilize the morphogenetic field of the tumor microenvironment thus contributing to inflammation, angiogenesis and progression.”
Damaged mitochondria can also cause cancer even when their DNA is intact, and Seyfried after Warburg makes a strong case that mitochondrial damage is the root cause of cancer.
Changes in mitochondria—the ‘powerhouse’ of the cell—have been observed in cancer for a long time, but researchers have found only recently that mitochondrial activity and cellular metabolism are linked to certain cancers. However, the mechanism by which genetic mutations alter mitochondrial activity and promote tumor growth was unknown.
Based on the findings in this study, the team is now considering the possibility of adding mitochondrial inhibitors into the therapeutic mix for patients in this trial.http://ref. Some well-known cancer drugs (Gleevec, Herceptin) already target the fermentation metabolism.
But might it be safer and more effective to starve cancer cells by cutting carbohydrates in the diet to zero?
Some study say « yes »[http://ref, http://ref,http://ref,, http://ref, http://ref, http://ref, http://ref,) but the results are not all positive
A search of http://clinicaltrials.gov/ yields 25 trials (http://ref )of ketogenic diet variants for cancer treatment. Most are in early stages, 5 have been completed, 2 have results. In this study (http://ref,) the ketogenic diet, with or without chemotherapy, did not cure glioma. This small study (http://ref ) found modest benefits in a variety of advanced cancers. These results are consistent with many mouse studies, in which some benefit was recorded from the ketogenic diet, but not a dramatic difference. The most encouraging results I have found was a study( http://ref )in which 9 of 11 mice treated with a combination of radiation and a ketogenic diet were cured of brain cancer. Clearly, this is no miracle cure, but it’s too early to give up–we’re just figuring out how to make the diet work, and it has not yet been tried except at late stages, after all else has failed.
There are a better option in the context of Nutrtion than Ketogenic diet, that explain in future conference
But the most important : When you think about CANCER you need to think about PREVENTION